Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Swiss Indoors Basel
|
Quarter Finals | David Goffin |
7-6
6-3 |
| 2016 |
Internazionali BNL d'Italia
|
1/16 | David Goffin |
4-6
4-6 |
| 2013 |
Winston-Salem
|
1/32 | David Goffin |
4-6
6-3 1-0 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/32 | James Duckworth |
6-3
6-1 |
| 2021 |
Dubai Tennis Championships
|
1/16 | Kei Nishikori |
6-3
7-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Biella 4
|
1/16 | Andreas Seppi |
6-4
3-6 3-6 |
