Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2016 |
BNP Paribas Masters
France, Paris |
1/16 | Richard Gasquet |
6-4
7-6 |
| 2016 |
AEGON Championships
England, London |
1/16 | Steve Johnson |
6-7
2-6 |
| 2012 |
US Open
|
1/16 | Richard Gasquet |
7-6
6-2 6-3 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Dubai Tennis Championships
|
1/16 | Hubert Hurkacz |
3-6
4-6 |
| 2021 |
Dubai Tennis Championships
|
1/32 | Richard Gasquet |
6-4
6-2 |
| 2021 |
Qatar Open
|
1/8 | Andrey Rublev | |
| 2021 |
Qatar Open
|
1/16 | Richard Gasquet |
6-4
6-4 |
| 2021 |
Murray River Open
|
1/32 | Mackenzie McDonald |
7-6
7-5 |
