Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2014 |
Heineken Open
New Zealand, Auckland |
1/16 | Steve Johnson |
5-7
7-6 4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2019 |
Wimbledon ATP
|
1/32 | Matteo Berrettini |
6-1
7-6 6-3 |
| 2019 |
Wimbledon ATP
|
1/64 | Marcos Baghdatis |
2-6
4-6 4-6 |
| 2019 |
Busan
|
1/16 | Marcos Baghdatis |
6-4
2-6 2-6 |
| 2019 |
Seoul
|
1/16 | Zhe Li |
4-6
2-6 |
