Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2015 |
Western & Southern Open, Qualification
|
1/14 (Special Qual) | Steve Johnson |
7-5
6-4 |
| 2014 |
Citi Open
|
1/32 | Steve Johnson |
6-3
7-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/16 | Alexander Bublik |
6-4
6-4 |
| 2021 |
Miami Open
|
1/32 | James Duckworth |
6-3
6-1 |
| 2021 |
Miami Open
|
1/64 | James Duckworth |
6-2
4-6 6-4 |
| 2021 |
Biella 3
|
1/16 | Andrea Arnaboldi |
4-6
3-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
