Sabalenka is Doha's defending champion, and won her only previous match with Muguruza.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Australian Open ATP
|
1/64 | James Duckworth |
3-6
2-6 4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Qatar Total Open
|
1/16 | Garbine Muguruza |
2-6
6-7 |
| 2021 |
Australian Open WTA
|
1/8 | Naomi Osaka |
6-4
4-6 5-7 |
| 2021 |
Australian Open WTA
|
1/16 | Garbine Muguruza |
6-1
6-1 |
| 2021 |
Australian Open WTA
|
1/32 | Garbine Muguruza |
6-3
6-1 |
| 2021 |
Australian Open WTA
|
1/64 | Garbine Muguruza |
6-4
6-0 |
| 2021 |
Yarra Valley Classic
|
Final | Ashleigh Barty |
7-6
6-4 |
| 2021 |
Yarra Valley Classic
|
Semi Finals | Garbine Muguruza |
1-6
0-6 |
| 2021 |
Yarra Valley Classic
|
Quarter Finals | Garbine Muguruza |
6-2
6-2 |
| 2021 |
Yarra Valley Classic
|
1/8 | Garbine Muguruza |
6-1
6-2 |
| 2021 |
Yarra Valley Classic
|
1/16 | Garbine Muguruza |
6-2
6-0 |
