Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2019 |
ASB Classic
|
Championship | ||
| 2018 |
Roland Garros ATP
|
1/32 | Steve Johnson |
6-4
6-7 2-6 2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Monte Carlo Masters
|
1/32 | Grigor Dimitrov |
6-3
6-4 |
| 2021 |
Sardegna Open
|
Quarter Finals | Nikoloz Basilashvili |
7-5
4-6 6-3 |
| 2021 |
Sardegna Open
|
1/8 | Jan-Lennard Struff |
4-6
2-6 |
| 2021 |
Sardegna Open
|
1/16 | Jan-Lennard Struff |
6-1
1-6 5-7 |
| 2021 |
Miami Open
|
1/16 | Roberto Bautista Agut |
6-4
3-6 2-6 |
| 2021 |
Miami Open
|
1/32 | Jan-Lennard Struff |
6-3
6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
