Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Volvo Car Open
|
1/16 | Yulia Putintseva |
2-6
2-6 |
| 2021 |
Volvo Car Open
|
1/32 | Zarina Diyas |
3-6
1-6 |
| 2021 |
Miami Open
|
1/32 | Belinda Bencic |
6-2
6-1 |
| 2021 |
Miami Open
|
1/64 | Zarina Diyas |
6-2
7-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
