Lopez, playing his record 75th successive Grand Slam, has won a five-setter in 21 of them.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Australian Open WTA
|
1/32 | Ashleigh Barty |
6-1
7-6 |
| 2021 |
Australian Open WTA
|
1/64 | Daria Gavrilova |
1-6
5-7 |
| 2021 |
Yarra Valley Classic
|
1/16 | Serena Williams |
1-6
4-6 |
| 2021 |
Yarra Valley Classic
|
1/32 | Daria Gavrilova |
2-6
0-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Andalucia Open
|
1/16 | Feliciano Lopez |
6-4
6-4 |
| 2021 |
Miami Open
|
1/64 | Alexei Popyrin |
4-6
6-7 |
