Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Copa Colsanitas
|
1/16 | Aliona Bolsova |
4-6
6-3 1-6 |
| 2021 |
Miami Open, Qualification
|
1/12 (Special Qual) | Kristina Kucova |
6-2
6-3 |
| 2021 |
Miami Open, Qualification
|
1/24 (Special Qual) | Anna Karolina Schmiedlova |
4-6
3-6 |
| 2021 |
Monterrey Open
|
Quarter Finals | Sara Sorribes Tormo |
3-6
5-7 0-0 |
| 2021 |
Monterrey Open
|
1/8 | Anna Karolina Schmiedlova |
6-2
2-6 2-6 |
| 2021 |
Monterrey Open
|
1/16 | Anna Karolina Schmiedlova |
6-4
6-0 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
