Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Serbia Open
|
1/16 | Marco Cecchinato |
1-6
4-6 |
| 2021 |
Monte Carlo Masters
|
1/16 | David Goffin |
6-4
6-0 |
| 2021 |
Monte Carlo Masters
|
1/32 | Marco Cecchinato |
6-4
6-3 |
| 2021 |
Monte Carlo Masters, Qualification
|
1/7 (Special Qual) | Marco Cecchinato |
1-6
3-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
