Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Monte Carlo Masters
|
1/32 | Marco Cecchinato |
6-4
6-3 |
| 2021 |
Monte Carlo Masters, Qualification
|
1/7 (Special Qual) | Marco Cecchinato |
1-6
3-6 |
| 2021 |
Sardegna Open
|
1/8 | Yannick Hanfmann |
7-5
6-1 |
| 2021 |
Sardegna Open
|
1/16 | Marco Cecchinato |
6-4
4-6 6-3 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
