Andy Murray  vs. Sam Querrey 
Querrey beat Novak Djokovic at Wimbledon last year. Is another shocker from the American a possibility in this Centre Court opener on Wednesday? It’s a stretch. Murray is 7-1 against Querrey, his only loss coming seven years ago on hard courts in Querrey’s hometown. In general, Murray’s wins haven’t been close, either. Querrey has the weapons—serve, forehand—to win points against Murray, but not to win them over and over the way he needs to do against the ultra-consistent Scot in a best of five.
Marin Cilic  vs. Gilles Muller 
Often the players who have been winning in the weeks before a Slam, and who you think could be dark horses ... don’t end up being dark horses. See Feliciano Lopez at Wimbledon this year. In the case of Cilic and Muller, though, form has held true; Muller won a title on grass in Holland, Cilic reached the final on that surface at Queen’s and here they are playing for their first trip to the Wimbledon semis. As amazing as Muller’s effort was against Rafael Nadal, and as well-equipped as he is for grass, Cilic will be favored. He beat Muller at Queen’s, and hasn’t dropped a set at Wimbledon.
Roger Federer  vs. Milos Raonic 
Top billing on Centre Court goes to this rematch of last year’s semifinal win by Raonic. When Federer limped off a fifth-set loser, and took the rest of the season off, many thought he might never return to this or any other court. Now here he is, 12 months later, the favorite to win it all again. Despite his loss to Raonic last year, he’s a strong favorite to get revenge on Wednesday. While Federer has yet to drop a set, Raonic is lucky to have survived his fourth-rounder against Alexander Zverev. The German helped him back into that match; the Swiss probably won’t.
Novak Djokovic  vs. Tomas Berdych 
At 31, Berdych continues to surprise. Last year at Wimbledon he reached the semis for the first time since 2010, and now he’s fresh off a five-set win over one of the stars of the future, Dominic Thiem. With Djokovic still finding his way back to top form, this might seem like a prime opportunity for him to get his first win over Djokovic in 12 matches, and his third in 28 meetings. On second thought, looking at those numbers, forget I mentioned it.
—GRAND SLAM WEEK: Watch Wimbledon Primetime on Tennis Channel, and catch up on the other 2017 Grand Slams on Tennis Channel Plus
—Watch encores from the 2017 French Open and Australian Open on Tennis Channel Plus, including matches like the AO Final showdown between Serena & Venus Williams