It was the second title of the season for Raonic, who collected his third straight San Jose title in February.
"I think I'm playing great tennis, I'm serving really well, I'm doing a lot of good things," Raonic said. If I keep that up I think I'll have opportunities and will put myself in a good position, no matter who [I play]."
The 11th-ranked Canadian won 95 percent of his first-serve points (41 of 43) and scored the lone break in the second set. Raonic wrapped up the win in one hour, 17 minutes to raise his record to 2-0 against the sixth-ranked Czech. Raonic also beat Berdych in the 2012 Cincinnati Masters tournament.
"He was exceptional. He was serving really well and didn’t give me many chances," Berdych, the only Top 10 player yet to win a title in 2013, told ATP World Tour.com. "Basically, the match was about two points. Both of them Milos handled better and so he deserved to win."
In the doubles final, the third-seeded team of Jamie Murray of Great Britain and John Peers beat fourth-seeded Tomasz Bednarek and Johan Brunstrom 6-3, 3-6, 10-6.
Raonic, who beat defending champion Richard Gasquet in the semifinals, raised his career record against Top 20 opponents to 12-20 in continuing his quest for a spot in the season-ending ATP World Tour Finals in London. He trails Jo-Wilfried Tsonga by 180 points for the 10th spot in the ATP Race to London. The top eight men qualify for the season-ending event. World No. 3 Andy Murray, who underwent back surgery earlier this week, is questionable to play the World Tour Finals.