The Spaniard has won 12 ATP tournaments — all on clay, and six on the annual Latin American swing.
No. 4 seed Tommy Robredo defeated fellow Spaniard Pablo Carreno Busta, 7-6 (5), 6-3. Eighth-seeded countryman Pablo Andujar advanced against Julian Reister of Germany 6-4, 6-3. In an all-Argentine match, No. 7 seed Juan Monaco beat Horacio Zeballos, 6-3, 6-1.
In the combined ATP-WTA event, top-seeded Klara Zakopalova of the Czech Republic won her first-round match, beating Colombia's Mariana Duque-Marino 6-4, 6-4.